181 Massachusetts Avenue — Lease in Cambridge, MA

  • Price: Contact for price
  • Listing type: For lease
  • Asset type: Retail Business
  • Location: Cambridge, MA 02139

Photos

181 Massachusetts Avenue — Lease in Cambridge, MA, photo 1 of 1

Description

Kendall Square / MIT Retail Space for Lease 1,876 SF of prime retail space available on the street level of the 850,000 SF Novartis Institutes for BioMedical Research building and across the street from its global research headquarters in Cambridge, MA.

Market Context

This retail in Cambridge, MA is listed for lease. Compare it against other retail listings for lease in Cambridge, MA — view the full market.

As of Q4 2025, the Boston retail market showed a 3.2% vacancy rate, average asking rents near $24.93/SF/yr, rents up 2.5% year over year, and cap rates around 7.3%. Source: Matthews Q4 2025 market report.

Rising rents point to a competitive market where well-priced, well-located space leases quickly.

Retail market FAQ

What is the typical cap rate for retail in Boston?
About 7.3% as of Q4 2025, per Matthews.
Is the Boston retail market tightening or softening?
Vacancy is around 3.2%, with asking rents rising year over year (Q4 2025).

Estimated Market Rate

$11.86/SF/mo – $16.04/SF/mo

Mid: $13.95/SF/mo

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